Kit inhibitor APcK110 extends survival in an AML xenograft mouse model
نویسندگان
چکیده
منابع مشابه
Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells.
Kit is a membrane-bound tyrosine kinase and receptor for stem cell factor (SCF) with a crucial role in hematopoiesis. Mutations of KIT occur in almost half of patients with core-binding factor leukemias, in which they have been associated with worse outcome. Development of new compounds targeting Kit may therefore hold promise for therapy. We investigated the activity and mechanism of action of...
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ژورنال
عنوان ژورنال: Investigational New Drugs
سال: 2010
ISSN: 0167-6997,1573-0646
DOI: 10.1007/s10637-010-9459-6